Excess Weight Gain
......Leptin To The Rescue!
by Dr. Peter H Kay
(Preston, UK)
Introduction
Many people would like to be slimmer, lose weight and have a healthier body mass index(BMI). Weight can be lost by increasing exercise. However, for some people, increased exercise may pose an undesirable health risk.
Another way to lose weight is to eat less food. This is very difficult for many people because, to satisfy their insatiable appetites, they have an overwhelming urge to eat lots of food. This common urge is reflected by the popularity of buffet style food outlets.
To suppress the feeling of hunger and eat less, apart from the use of appetite suppressing drugs, anorectics, many subject themselves to various surgical interventions, not without dangers, to limit their food intake. A safer approach to appetite suppression would be of great benefit.
Leptin, the appetite suppressant.
Over a decade ago, scientists discovered a gene, “ob” now called LEP, that plays an important role in appetite suppression. The LEP gene produces the appetite controlling hormone leptin.
Scientists found that an unusual strain of mouse that readily becomes obese due to its voracious appetite had a defective LEP gene, it did not produce enough leptin. It was later discovered that the appetites of these leptin deficient obese mice could be controlled by leptin replacement therapy. Humans with leptin deficiency also have voracious appetites and suffer profound obesity.
As with the obese mice, their appetites can be controlled and weight lost by administration of leptin, confirming that leptin plays an important role in suppressing the appetite and weight control . It follows that boosting LEP activity would reduce the appetite and promote weight loss.
Scientists have also shown that as overweight people lose weight, leptin levels fall . As a result, the urge to over-eat increases and weight is regained. Once weight is lost, increasing leptin activity plays an important role in maintaining the desired BMI.
A “sluggish” ancestral LEP gene?
Interestingly, most of us are aware of a small number of people who are slim because they have what is considered to be a “poor” appetite and are quite satisfied with consumption of small amounts of food; they cannot do justice to the “eat all you can” food outlets.
It remains to be determined whether, in contrast to those with a poor appetite, most people have inherited a sluggish form of the LEP gene, because a poorly acting LEP gene would have helped our ancestors to survive much better because they would have been able to eat more when food was plentiful and store it as fat to help them survive in times of famine.
If that were the case, then most people now, who had inherited a sluggish ancestral form of the LEP gene will also have a greater likelihood of fracturing their bones and increased susceptibility to development of late onset diabetes.
Why, because firstly, studies have shown that leptin plays a very important role in increasing bone density, reducing the likelihood of bone fractures, particularly in post-menopausal women. Bone is continually being remodeled, old bone is being replaced by new bone. Leptin promotes new bone formation in a dose dependent manner 1, so, low leptin activity is associated with reduced new bone development.
Secondly, it was previously thought that late onset diabetes, associated with obesity was relieved simply as a consequence of leptin induced weight loss. Now, scientists at Rockefeller University have made the exciting discovery that leptin can correct late onset diabetes independently of its role in weight loss. In other words, even if weight is not lost, leptin can still play a very important role in correcting diabetes 2.
The solution:
Simply helping the LEP gene to work better would be an effective way to lose weight, maintain a healthy BMI and help to avoid development of diseases such as late onset diabetes.
The Homeovitality Super Weight-Loss product, a health supplement developed in Australia by the world renowned molecular geneticist Dr. Peter H. Kay has been designed to do exactly that. The Homeovitality system is based on the proven drug free gene targeting principles of New Homeopathy, developed by Dr. Marichal in which immune response genes are targeted by highly diluted DNA molecules.
Homeovitality Super Weight-Loss has been formulated to help people lose weight more effectively by targeting the ADP gene as well, helping to reduce fat deposition. A poorly acting ADP gene predisposes to excessive weight gain
The revolutionary Homeovitality weight loss product can be obtained via eBay and searching under “homeovitality” or online by contacting www.homeovitality.co.uk
More information can be found by accessing the www.wellnesshp.com website
The author can be contacted on peterhkay@gmail.com.
References:
1. Blain H, et al., Serum leptin level is a predictor of bone mineral density in postmenopausal women. J. Clin. Endocrinol. & Metab. 87:1030-1035, 2002.
2. Hedbacker K, et al., Antidiabetic effects of IGFBP2, a leptin regulated gene. Cell Metab.11:11-22, 2010.
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